Matt Faltyn

Matt Faltyn

Co-Founder & CTO @ Trilemma Capital

Posts by Collection

portfolio

ODEs vs LSTM-RNNs: Modeling HIV Viral Dynamics

We train and evaluate several Long Short-Term Memory-Recurrent Neural Network models in the task of predicting HIV viral dynamics using a synthetic dataset generated from running simulations of a phagocytosis based logistic clearance model.

publications

Evolution and Nomenclature of the Trimethoprim Resistant Dihydrofolate (dfr) Reductases

Published in Preprints, 2019

With the increasing use of genome sequencing as a surveillance tool for molecular epidemiology of antimicrobial resistance (AMR), databases and clear nomenclature for AMR gene families are critical. Due to the convoluted nomenclatural history of the integron-associated trimethoprim-resistant dihydrofolatereductase (dfr) gene family, we decided to conduct a literature review, comparative sequence analysis, and phylogenetic investigation of the dfr family, the results of which are presented here and available at the Comprehensive Antibiotic Resistance Database (CARD). Overall, literature review and phylogenetic analysis resolved gene name synonyms based on sequence. We recommend adoption of phylogenetic methods to help guide AMR gene naming efforts and relegation of misleading names to synonyms.

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The Perinatal Mental Health of Indigenous Women: A Systematic Review and Meta-Analysis

Published in The Canadian Journal of Psychiatry, 2019

Although Indigenous women are exposed to high rates of risk factors for perinatal mental health problems, the magnitude of their risk is not known. This lack of data impedes the development of appropriate screening and treatment protocols, as well as the proper allocation of resources for Indigenous women. The objective of this systematic review and meta-analysis was to compare rates of perinatal mental health problems among Indigenous and non-Indigenous women.

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CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database

Published in Nucleic Acids Research, 2019

The Comprehensive Antibiotic Resistance Database (CARD; https://card.mcmaster.ca) is a curated resource providing reference DNA and protein sequences, detection models and bioinformatics tools on the molecular basis of bacterial antimicrobial resistance (AMR). CARD focuses on providing high-quality reference data and molecular sequences within a controlled vocabulary, the Antibiotic Resistance Ontology (ARO), designed by the CARD biocuration team to integrate with software development efforts for resistome analysis and prediction, such as CARD’s Resistance Gene Identifier (RGI) software. Since 2017, CARD has expanded through extensive curation of reference sequences, revision of the ontological structure, curation of over 500 new AMR detection models, development of a new classification paradigm and expansion of analytical tools. Most notably, a new Resistomes & Variants module provides analysis and statistical summary of in silico predicted resistance variants from 82 pathogens and over 100 000 genomes. By adding these resistance variants to CARD, we are able to summarize predicted resistance using the information included in CARD, identify trends in AMR mobility and determine previously undescribed and novel resistance variants. Here, we describe updates and recent expansions to CARD and its biocuration process, including new resources for community biocuration of AMR molecular reference data.

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Psychological problems in parents of children and adolescents with chronic pain: a systematic review and meta-analysis

Published in Psychology, Health & Medicine, 2020

Pediatric chronic pain conditions impose substantial suffering on youth and the stress and suffering associated with these problems can affect the mental health of parents. The objective of this review is to describe and quantify links between youth chronic pain and parental mental health. A systematic search of five electronic databases was conducted from their inceptions to December 2019. Studies were included if they had an observational study design, recruited parents of youth aged 0–18 years and suffering from chronic pain, and mental health outcomes were assessed in parents. Of the seven studies that met our inclusion criteria, two were eligible for meta-analysis and suggested that the mental health of these parents may be worse overall. While this finding was not statistically significant, it was supported by a number of other eligible studies. Research also suggests that child pain may increase the frequency but not intensity of stress events for parents, that mothers may experience a greater burden of psychological symptoms than fathers, and that the parents of youth with chronic pain may exhibit better social functioning. More research is needed to clarify the nature of the mental health risks present in parents of youth with chronic pain.

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Exploring Links Between Prenatal Adversity and Adolescent Psychiatric Risk in a Canadian Population-Based Sample

Published in Journal of Developmental & Behavioral Pediatrics, 2021

Adverse prenatal and postnatal exposures may have long-lasting effects on health and development. However, it remains unclear whether being exposed to a greater number of prenatal adversities affects mental health risk. The current study examined whether exposure to maternal health problems prenatally is associated with an increasing risk of psychiatric morbidity in adolescents.

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Quantitative ultrasound characterization of therapy response in prostate cancer in vivo

Published in American Journal of Translational Research, 2021

Quantitative ultrasound (QUS) is a non-invasive imaging modality that permits the detection of tumor response following various cancer therapies. Based on ultrasound signal scattering from the biological system, scatterer size, and concentration of microscopic scatterers, QUS enables the rapid characterization of tumor cell death. In this study, tumor response to ultrasound-stimulated microbubbles (USMB) and hyperthermia (HT) in tumor-bearing mice, with prostate cancer xenografts (PC3), was examined using QUS. Treatment conditions included 1% (v/v) Definity microbubbles stimulated at ultrasound pressures (0, 246, and 570 kPa) and HT treatment (0, 10, 40, and 50 minutes). Three ultrasound backscatter parameters, mid-band fit (MBF), 0-MHz spectral intercept (SI), and spectral slope (SS) were estimated prior to, and 24 hours after treatment. Additionally, histological assessment of tumor cell death and tissue microstructural changes was used to complement the results obtained from ultrasound data. Results demonstrated a significant increase in QUS parameters (MBF and SI) followed combined USMB and HT treatment (P<0.05). In contrast, the backscatter parameters from the control (untreated) group, and USMB only group showed minimal changes (P>0.05). Furthermore, histological data demonstrated increased cell death and prominent changes in cellular and tissue structure, nucleus size, and subcellular constituent orientation followed combined treatments. The findings suggested that QUS parameters derived from the ultrasound backscattered power spectrum may be used to detect HT treatment effects in prostate cancer tumors in vivo.

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In vivo assessment of prostate cancer response using quantitative ultrasound characterization of ultrasonic scattering properties

Published in BMC Cancer, 2021

The study here investigated quantitative ultrasound (QUS) parameters to assess tumour response to ultrasound-stimulated microbubbles (USMB) and hyperthermia (HT) treatment in vivo. Mice bearing prostate cancer xenografts were exposed to various treatment conditions including 1% (v/v) Definity microbubbles stimulated at ultrasound pressures 246 kPa and 570 kPa and HT duration of 0, 10, 40, and 50 min. Ultrasound radiofrequency (RF) data were collected using an ultrasound transducer with a central frequency of 25 MHz. QUS parameters based on form factor models were used as potential biomarkers of cell death in prostate cancer xenografts.

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Evaluating the effectiveness and quality of mobile applications for perinatal depression and anxiety: A systematic review and meta-analysis

Published in Journal of Affective Disorders, 2021

Our objectives were to assess: (1) the effectiveness of existing mHealth apps for reducing symptoms of maternal depression and/or anxiety during the prenatal period and/or the first year postpartum, and (2) the app quality of commercially available apps targeting perinatal depression and/or anxiety.

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Cyclic Vomiting Syndrome in the Emergency Department: A 10-Year Review of Clinical Presentation and Management

Published in Pediatric Emergency Care, 2022

The aims of the study were (1) to determine how frequently patients with cyclic vomiting syndrome (CVS) present to the pediatric emergency department (ED) with CVS-related symptoms, (2) to identify variables in clinical presentation that occur frequently in patients with multiple ED visits, and (3) to compare ED management of CVS with recommended guidelines.

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talks

teaching

Teaching experience 1

Undergraduate course, University 1, Department, 2014

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Teaching experience 2

Workshop, University 1, Department, 2015

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